Spatiotemporal Brain Dynamics During Cyclic Seizures of Super-Refractory Status Epilepticus.

ABSTRACT:

Background

Cyclic seizures (CS) are defined by the periodic recurrence of epileptic activity and may offer critical insights into the mechanisms of seizure termination. Previous studies have reported increased network synchronization during the final stages of seizures. The objective of this study was to investigate hypersynchronization at the termination of cyclic seizures and to characterize its spatial distribution.

Material and methods

To quantify brain synchronization, we calculated the imaginary coherence in a low-frequency band (LF-iCOH) at different ictal phases. Synchronization was calculated at both scalp regions and electrode levels. A total of 10 patients were selected, and 1230 seizures from 468 h of EEG monitoring were analyzed.

Results

Eight patients ex

SUBMITTER: Ledos A 

PROVIDER: S-EPMC12658284 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature