Monte Carlo simulations of geometric deformation of Harrison-Anderson-Mick applicators used in intraoperative radiation therapy.

ABSTRACT:

Background

The Harrison-Anderson-Mick (HAM) applicator is a high-dose-rate intraoperative radiotherapy (HDR-IORT) applicator used to position Ir-192 brachytherapy sources over surgically-accessed tumor volumes or post-resection tumor beds. Because of the lack of a 3D imaging system, dwell times are optimized pre-surgery by a TG-43-based treatment planning system (TPS) that assumes a perfectly flat applicator surface surrounded by an infinite water phantom. These assumed conditions are disparate from typical treatment conditions, especially in the pelvic regions, which often involve uneven patient surfaces and superficial irradiations with little to no backscatter material.

Purpose

Develop and validate a Monte Carlo (MC) model of HDR-IORT treatment with a HAM applicator and u

SUBMITTER: Insley B 

PROVIDER: S-EPMC12658346 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature