Study on the relationship between insomnia disorder, PET/CT, and gut microbiota in patients with Alzheimer's disease.

ABSTRACT:

Objective

Previous studies on Alzheimer's disease (AD) have focused on the relationships between brain pathology and gut microbiota, brain pathology and sleep, and sleep and gut microbiota, but no study has explored the relationship between these three factors. Therefore, we integrated these three factors into a unified framework and aimed to provide a reference for treating insomnia disorders (ID) in patients with AD.

Patients/methods

The 65 patients diagnosed with AD were categorized into ID group (n = 30) and non-ID group (n = 35) according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. ¹⁸F-fluorodeoxyglucose (FDG)-positron emission tomogra

SUBMITTER: Kang J 

PROVIDER: S-EPMC12658357 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature