The bidirectional association between depression and sarcopenia: a systematic review and meta-analysis.

ABSTRACT:

Background

Sarcopenia, a geriatric syndrome characterized by progressive loss of muscle mass, strength, and physical performance, elevates risks of functional decline and mortality. This study aims to investigate the co-occurrence patterns between depression and sarcopenia and characterize their epidemiological linkages.

Methods

We systematically searched PubMed, Embase, Scopus, and Web of Science for studies examining depression and sarcopenia (published by July 12, 2024). Our review encompasses literature on sarcopenia prevalence, its co-occurrence with depression, and the odds ratio (OR) between these conditions. We performed statistical analyses using R.

Results

Analysis of 36 studies demonstrated significantly higher pooled depression prevalence among sarcopenic

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12658358 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature