Protective effects of α-ketoglutaric acid on palmitic acid-induced deterioration in sheep endometrial epithelial cells via ferroptosis inhibition.

ABSTRACT:

Introduction

Emerging evidence indicates that dysregulated palmitic acid (PA) homeostasis plays a key role in inducing lipotoxicity and cellular dysfunction in mammalian endometrial epithelial cells. While this phenomenon has been documented in bovine models, the underlying mechanisms of PA-induced toxicity in sheep endometrial epithelial cells (SEECs) remain poorly understood. Moreover, effective strategies to counteract PA-mediated damage in SEECs have yet to be fully explored.

Methods

In this study, we investigated the protective effects of α-ketoglutaric acid (α-KG), a central metabolic intermediate in the tricarboxylic acid (TCA) cycle, against PA-induced cellular impairment in SEECs. Functional assays were performed to assess changes in cell viability, proliferation, m

SUBMITTER: Bai Z 

PROVIDER: S-EPMC12658361 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature