Coffee Consumption and Risk of Incident Gastrointestinal Disease: A Large Prospective Cohort Study.

ABSTRACT: Coffee's health effects are well studied, but its relationship with gastrointestinal diseases (GIDs) remains unclear, particularly with the frequent use of sweeteners. A prospective cohort of 147,263 participants without pre-existing GIDs was analyzed. Coffee intake, assessed via a 24-h dietary recall, was categorized as unsweetened, naturally sweetened, or artificially sweetened. Incident GIDs were identified through medical records. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs). Genetic predisposition was assessed using polygenic risk scores (PRS), with subgroup and sensitivity analyses conducted for robustness. Over a 12.6-year median follow-up, 29,118 incident GIDs occurred. Unsweetened coffee showed a dose-dependent, U-shaped associat

SUBMITTER: Zhou S 

PROVIDER: S-EPMC12658384 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature