Unraveling the Clinical and Molecular Landscape of Myocardial Infarction in Behcet's Syndrome: A Comprehensive Analysis.

ABSTRACT:

Objectives

Behçet's syndrome (BS) is a rare inflammatory disorder with life-threatening complications like myocardial infarction (MI), driven by vasculitis and immune-mediated thrombosis. This study unveils distinct clinical and molecular profiles in BS patients with MI, employing gene analysis and Weighted Gene Co-expression Network Analysis (WGCNA) to pinpoint critical pathways and therapeutic targets, enhancing diagnostic precision and treatment efficacy.

Methods

A total of 2358 BS patients (25 with MI, 2333 without MI) were analyzed. Clinical characteristics were compared based on the cohort. Differential gene expression analysis was performed on four microarray datasets, by using GEO datasets, and WGCNA identified key gene modules. KEGG/GO enrichment revealed disease pa

SUBMITTER: Zhang LY 

PROVIDER: S-EPMC12658460 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature