Association of paternal preconception hepatitis B virus infection with the risk of preterm birth between 2010 and 2020 in China: a population-based cohort study.

ABSTRACT:

Introduction

Hepatitis B virus (HBV) has recently been reported to impair both sperm and oocyte function, potentially increasing infertility and birth defects risks, although primarily recognised as a concern for mother-to-child transmission. Population-based evidence regarding the association between paternal preconception HBV infection and preterm birth (PTB) risk is absent.

Methods

This retrospective cohort study was conducted based on the National Free Preconception Checkups Project between 22 April 2010 and 31 December 2020 in China. Paternal preconception HBV infection statuses were divided into three groups: uninfected, past exposure and immunity, and current infection. Inverse probability weighting (IPW) via propensity models was used to adjust for imbalance by diffe

SUBMITTER: Zhao C 

PROVIDER: S-EPMC12658487 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature