Trial characteristics, methods and reported challenges of decentralised clinical trials: a scoping review.

ABSTRACT:

Objectives

To map the landscape of decentralised clinical trials (DCTs) by summarising characteristics, methods and reported challenges of published DCTs.

Design

Scoping review, reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) checklist.

Data sources

Ovid MEDLINE and PubMed were searched through to 21 August 2024.

Eligibility criteria

We included reports of completed DCTs (defined as a trial of an intervention, with a comparison arm, in which some or all trial activities occurred away from the trial centre). All intervention types were included.

Data extraction and synthesis

A single reviewer extracted data to a structured extraction sheet. Descriptive statistics (frequencies) a

SUBMITTER: Cussen A 

PROVIDER: S-EPMC12658491 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature