Design and Development of Sulfonamide-Chalcones as Antiepileptic Candidates: Computational and Zebrafish-Based Validation Approaches.

ABSTRACT: The study aims to develop safer and more effective antiepileptic drugs (AEDs) by targeting the γ-aminobutyric acid type A (GABA_A) receptor, an important inhibitory neurotransmitter system involved in the control of neuronal excitability and seizures. With epilepsy rates rising worldwide and current AEDs often causing serious side effects, new neurotherapeutics with better efficacy and safety are urgently needed. In this context, sulfonamides, known for their proven anticonvulsant properties, were selected as the core scaffold for the development of new sulfonamide-chalcone hybrids (compounds 1-36) as potential AED candidates. These compounds were analyzed for their drug-likeness, ADMET profiles, and electronic properties using density functional theory (DFT) calcul

SUBMITTER: Adzahar AN 

PROVIDER: S-EPMC12658612 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature