Electrospun Polycaprolactone Scaffolds with Marine-Derived Biosilica Nanoparticles (<i>Dragmacidon reticulatum</i>) for Bone Tissue Engineering Applications.

ABSTRACT: Critical bone fractures require biomaterials capable of promoting efficient regeneration, with polymeric scaffolds with a bioactive phase being a promising approach. This study investigated the effect of the incorporation of different amounts (10, 15, and 20% w/w) of biosilica nanoparticles (nBS) extracted from the sponge Dragmacidon reticulatum within biodegradable polymer matrices based on poly-(ε-caprolactone) (PCL), with and without alkaline surface modification to increase polarity. Composites were processed by electrospun and casting, and the effect of the interconnected porosity on the structure, surface functionalization, and bioactivity was evaluated by comparison with the nonporous films' counterparts. Electrospinning generated nanofibrous membranes with better nBS dispers

SUBMITTER: do Espirito Santo G 

PROVIDER: S-EPMC12658661 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature