Multi-Isotope Internal Standardization for Inductively Coupled Plasma Mass Spectrometry.

ABSTRACT: Recent developments in trace analyte determination have evolved from the traditional relationship relating analyte signal to concentration to "multisignal" methods where both axes are measured instrumental signals. However, many multisignal methods are limited in some fashion: Some have low sample throughput, some result in poor accuracies in difficult sample matrices, and others require several significant signals for each analyte species. Multi-isotope internal standardization (MIIS) is a newly developed calibration method for inductively coupled plasma mass spectrometry (ICP-MS) that addresses the issues presented by other multisignal techniques. Multiple isotope masses for both the analyte species and several internal standards are used to build a calibration curve. Only two solutions

SUBMITTER: DeCourcey MX 

PROVIDER: S-EPMC12658662 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature