Maternal Use of Integrase Strand Transfer Inhibitors During Pregnancy and Infant Neurodevelopment.

ABSTRACT:

Importance

Current perinatal HIV treatment guidelines recommend inclusion of integrase strand transfer inhibitors (INSTIs), but few studies have evaluated the safety of INSTIs for infant neurodevelopment.

Objective

To compare the neurodevelopment of infants born between 2012 and 2023 with in utero exposure to INSTI-containing antiretroviral treatment (ART) regimens with that of infants exposed to protease inhibitor (PI)-containing or nonnucleoside reverse transcriptase inhibitor (NNRTI)-containing regimens.

Design, setting, and participants

This prospective cohort study was conducted in 22 US-based academic research centers among women with HIV and their uninfected infants born between January 1, 2012, and December 31, 2023, and exposed in utero to INSTI-based, PI-bas

SUBMITTER: Williams PL 

PROVIDER: S-EPMC12658668 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature