Genomic and In Vivo Characterization of Antimicrobial Resistance and Virulence in UPEC <i>Escherichia coli</i> Isolated from Brazilian Cases of UTI.

ABSTRACT: With the growing global prevalence of antimicrobial resistance, the treatment of urinary tract infections caused by Escherichia coli is becoming increasingly challenging. Uropathogenic E. coli (UPEC) is responsible for approximately 80% of urinary infections worldwide and possesses extraordinary genetic plasticity that facilitates both antimicrobial resistance and virulence. This study aimed to characterize the genomic profiles of four clinical UPEC strains (SJR07, SJR30, SJR31, and SJR49) that were recently isolated from women with UTIs in the city of Divinópolis, Brazil. Through whole-genome sequencing and comparative analysis, we identified a high degree of genetic diversity, including a heterogeneous repertoire of resistance and virulence genes located on plasmids and gen

SUBMITTER: Cardoso BG 

PROVIDER: S-EPMC12658690 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature