Multifunctional Dynamic Hydrogel Based on a Micelle-Cross-Linked Chitosan Network for Infected Wound Healing.

ABSTRACT: Despite significant advancements in the development of hydrogel dressings for wound healing, there remains a highly urgent demand to create multifunctional hydrogels with satisfying biocompatibility, self-healing ability, adhesiveness, appropriate mechanical properties, antibacterial activity, and therapeutic effects. Herein, a versatile hydrogel dressing was prepared through the cross-linking of terminally aldehyde-modified Pluronic-F127 (AF127) micelles with dihydrocaffeic acid-functionalized chitosan (CA) via the formation of a dynamic Schiff base. The cooperation of chitosan grafted with multiple catechol groups and the dynamic nature of the Schiff base imparted the hydrogel with superior antioxidant properties, adhesiveness, rapid self-healing, intrinsic antibacterial activity, and pH

SUBMITTER: Wang C 

PROVIDER: S-EPMC12658702 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature