Interaction Between Photoperiod and Sex on Hepatic Lipid Homeostasis in Rats Fed an Obesogenic Diet.

ABSTRACT: Seasonal changes in day length as well as sex are critical factors influencing metabolic processes. However, their combined impact on liver lipid metabolism under obesogenic conditions remains unclear. This study aims to investigate the interaction between sex and photoperiod on liver lipid homeostasis in obese Fischer 344 (F344) rats, with a special emphasis on the underlying molecular mechanisms. To this aim, male and female rats were fed with a cafeteria diet (CAF) for 11 weeks and exposed to either long (L18, 18 h of light/day) or short (L6, 6 h of light/day) photoperiods for the last 8 weeks. Liver histological analysis, hepatic damage markers, plasmatic and hepatic lipid profiles as well as hepatic gene expression related to lipid metabolism were performed. Results indicate that male

SUBMITTER: Gomez-Roncal S 

PROVIDER: S-EPMC12658719 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature