Suppression of cathepsin B attenuates myocardial injury via limiting cardiomyocyte apoptosis.

ABSTRACT:

Background

Inflammation plays a pivotal role in modulating the pathophysiological progression of myocardial injury and the subsequent repair and remodeling of the infarcted myocardium. Cathepsin B, a member of the cysteine protease family, has been recognized for its ability to initiate various signaling cascades essential to inflammatory processes. This study aims to investigate whether cathepsin B influences cardiomyocyte survival under inflammatory conditions.

Methods

Mice were randomly divided into four groups (n = 6 per group) based on whether they received an intraperitoneal injection of Ca-074 Me (50 mg/kg) and whether myocardial ischemia/reperfusion (I/R) surgery was performed.

Results

The cathepsin B-specific inhibitor Ca-074 Me significantly attenuate

SUBMITTER: Su R 

PROVIDER: S-EPMC12658728 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature