C-reactive protein-to-albumin ratio in peripheral artery disease.

ABSTRACT:

Aim

The aim of this study was to assess the prognostic performance of the C-reactive protein-to-albumin ratio (CAR) in predicting mortality and amputation of peripheral artery disease (PAD) patients undergoing endovascular therapy (EVT).

Methods

We conducted a systematic search from the inception date to June 12, 2025, in eight databases and a manual search to cover gray literature. High and low CAR were defined according to the optimal cut-off from each study. Meta-analysis was performed to pool prognostic performance.

Result

A total of 1,451 subjects from five observational studies were included. The prevalence of mortality and amputation was 4.7 and 21.4%, respectively. Pre-procedural high CAR was associated with a higher risk of mortality (risk ratio [RR] 3.11; 95

SUBMITTER: Saputra PBT 

PROVIDER: S-EPMC12658729 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature