Comparison of ¹⁸F-Choline PET/CT and ^99mTc-Sestamibi SPECT/CT in the Localization of Hyperactive Parathyroid Glands in Primary Hyperparathyroidism: Diagnostic Performance in Discordant Cases.

ABSTRACT:

Introduction

Accurate localization of hyperactive parathyroid glands is essential in managing primary hyperparathyroidism. Despite advances in imaging, discordant findings still complicate surgical planning. Tc-99m-sestaMIBI SPECT/CT (MIBI SPECT/CT) and ¹⁸F-Choline PET/CT (FCH PET/CT) are commonly used, particularly when localization is discordant.

Objective

This study compared the findings of FCH PET/CT and MIBI SPECT/CT with intraoperative outcomes in patients who underwent parathyroidectomy for primary hyperparathyroidism. In discordant cases, the relative diagnostic performance and postoperative outcomes of the two modalities were analyzed.

Materials and methods

We retrospectively reviewed 133 patients who underwent parathyroidectomy between January 202

SUBMITTER: Kang S 

PROVIDER: S-EPMC12658743 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature