Peptide-Functionalized Nanopillared Surfaces with Tunable Antimicrobial and Immunomodulatory Properties.

ABSTRACT: Stimuli-responsive nanopatterned surfaces developed by physical and chemical modification with polymers, nanoparticles, and biomolecules have found various applications in biotechnology and biomedicines. In this study, bacterial capture and killing abilities of cicada wing-inspired, highly hydrophilic, nanopillared surfaces composed of poly-(methacrylic acid)-co-poly-(vinyl alcohol) are combined with cationic amphipathic peptides to develop antimicrobial and immunomodulatory materials with tunable properties. The peptide-modified surfaces prepared by layer-by-layer deposition were analyzed for the amount of peptide deposited and demonstrated significant changes in surface hydrophilicity and height of nanopillars upon biomolecule immobilization. The deposition of an antimicrobial pep

SUBMITTER: Jahan S 

PROVIDER: S-EPMC12658818 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature