<i>In Vitro</i> Properties of WMRK-gH625, a Novel Hybrid Peptide against Multidrug-Resistant Pathogens.

ABSTRACT: Antimicrobial resistance (AMR) poses a critical global health threat, driven largely by the misuse of antibiotics and the emergence of multidrug-resistant (MDR) pathogens. Antimicrobial peptides (AMPs) have emerged as promising alternatives to traditional antibiotics due to their broad-spectrum activity and low propensity for inducing resistance. This study presents the design, synthesis, and characterization of a novel fusion peptide, WMRK-gH625, which combines the antimicrobial activity of peptide WMR-K with the membrane-translocating capability of cell-penetrating peptide gH625. The hybrid peptide exhibited a helical conformation, enhanced membrane fusion and destabilization capabilities, and selective action against bacterial membranes without significant effects on eukaryotic cells. W

SUBMITTER: Scaglione E 

PROVIDER: S-EPMC12658822 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature