Integrated Analytical System for Comprehensive Two-Dimensional Enantio-Gas Chromatography and Low-Pressure Gas Chromatography Mass Spectrometry Utilizing a Switching Valve: Design and Optimization.

ABSTRACT: An analytical system was developed to perform both comprehensive two-dimensional enantio-gas chromatography mass spectrometry with the second-dimension column working under low-pressure conditions (eGC×LP-GC-QMS) and low-pressure gas chromatography mass spectrometry (LP-GC-QMS) analysis, without any changes to the instrumental setup. This is achieved using a switching valve, which also allows for back-flushing of the first-dimension column, thereby generating a flexible and powerful analytical platform. The eGC×LP-GC-QMS configuration can provide both targeted and untargeted information in a single run. In this research, it is employed for the analysis of 56 pesticides (without considering isomers), with the added capability of the backflush mode, effectively removing high-boiling compound

SUBMITTER: Rinaldi G 

PROVIDER: S-EPMC12658858 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature