SMART 2.0 Statistical Metabolomics Analysis: An R Tool 2.0.

ABSTRACT: Metabolomics has experienced significant growth and increased popularity due to technological advancements. We introduced an integrated tool for untargeted metabolomics analysis, SMART 1.0, that streamlined the entire analysis process, from initial data preprocessing to subsequent association analysis. With SMART 2.0, we enhanced SMART 1.0 by introducing new analytical modules in targeted metabolomics analysis, data normalization, quality control assessment, and advanced dimensionality reduction and classification methods. Additionally, SMART 2.0 offers integrative omics pathway analysis and postanalysis tasks such as peak identification and concentration calibration. We also explored the potential of using large language models for peak annotation and have found the results to be promisin

SUBMITTER: Liang YJ 

PROVIDER: S-EPMC12658861 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature