Polymer-lipid hybrid nanoparticles incorporating green coffee extract: enhancing treatment for hepatic steatosis and fibrosis through metabolomic insights.

ABSTRACT: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 30% of adults globally. Its severe form, metabolic dysfunction-associated steatohepatitis (MASH), results in liver damage due to a combination of steatosis and fibrosis. Green coffee extract (GCE) derived from unroasted coffee beans demonstrates therapeutic potential for MASLD/MASH attributed to its rich profile of bioactive compounds. However, challenges remain regarding bioavailability and understanding of mechanisms. In this study, we investigated the bioactive potential of GCE encapsulated in polymer-lipid hybrid nanoparticles (PLNs) as a therapeutic option for MASLD and associated fibrosis. Encapsulation of GCE into PLNs enhanced its physicochemical properties, including reduced particle size (191.5

SUBMITTER: Uriostegui-Campos MA 

PROVIDER: S-EPMC12658880 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature