Impact of growth conditions on the abundance and diversity of cultivable bacteria recovered from <i>Pheronema carpenteri</i> and investigation of their antimicrobial potential.

ABSTRACT: The deep sea is a largely unexplored extreme environment supporting a diverse biological community adapted to low temperatures and high pressures. Such environments support microbial life that may be a source of novel antibiotics and other drugs. Whilst this is often the case, many species with bioactive capabilities may be missed with traditional culturing methods. In this study, a total of 16 different concentrations and types of media were employed, to culture 389 bacterial isolates using Dilution to Extinction methods and Actinobacteria Directed Cultivation techniques. This generated 72 (18.6%) isolates with narrow and broad-spectrum activity against ESKAPE pathogens including Escherichia coli (E. coli), methicillin-resistant Staphylococcus aureus, and vancomycin-r

SUBMITTER: Conway J 

PROVIDER: S-EPMC12658890 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature