Effectiveness of Influenza Vaccines and Duration of Protection Against Hospitalisation in England: 2022/2023 and 2023/2024 Seasons.

ABSTRACT:

Background

Linkage of national, healthcare data can provide greater resolution of vaccine effectiveness (VE) against influenza subtypes, as well as the relative effectiveness of different vaccine types and the effects of waning on VE. We present 2022/2023 and 2023/2024 end-of-season VE against hospitalisation with laboratory confirmed influenza for England.

Methods

A test-negative design was used to estimate VE against hospitalisation. Cases and controls were identified within national laboratory surveillance systems and linked to hospital admission data. Vaccine histories were obtained from England's vaccine register. We combined results on VE by vaccine type over the two seasons using a meta-analysis.

Results

One hundred thousand five hundred eighty-one (28,565 posi

SUBMITTER: Whitaker HJ 

PROVIDER: S-EPMC12658907 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature