Effects of L-citrulline supplementation and watermelon intake on arterial stiffness and endothelial function in middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Objectives

To determine and explore the effects of L-citrulline supplementation and watermelon intake on arterial stiffness (AS) and endothelial function in middle-aged and elderly individuals.

Participants

Middle-aged and elderly adults.

Designs

A systematic review and meta-analysis of randomized controlled trials (RCTs).

Methods

A comprehensive search was conducted across four major electronic databases (PubMed, Cochrane, EMBASE, and Web of Science), covering the period from database inception to May 1, 2025. The quality of included studies was assessed using the Cochrane Risk of Bias Assessment tool 2.0. Data analysis was performed with RevMan 5.4.1 software; pulse wave velocity (PWV) data were analyzed using a random-effects model to pool effect sizes, whil

SUBMITTER: Luo P 

PROVIDER: S-EPMC12658987 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature