Isocitrate Dehydrogenase-Mutant WHO Grade 4 Astrocytoma with BCOR Alteration: Case Report.

ABSTRACT:

Introduction

BCOR, a transcriptional regulator and component of the noncanonical polycomb repressive complex 1 (PRC1), plays an important role in tumorigenesis through transcriptional repression mediated by histone modifications. Alterations in BCOR, including nonsense, frameshift, and splice site mutations, have been reported in several brain tumors such as glial tumors, astroblastomas, pineoblastomas, and medulloblastomas. However, BCOR alterations have not previously been described in IDH-mutant WHO grade 4 astrocytoma.

Case presentation

We describe an adult patient who presented with a recurrent, contrast-enhancing tumor in the left parietal region. The patient underwent complete surgical resection, and histopathology confirmed an IDH-mutant WHO grade 4 astrocytoma. Next

SUBMITTER: Kurdi M 

PROVIDER: S-EPMC12659008 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature