Association between multimarkers of metabolic malnutrition and inflammation and risk of chronic obstructive pulmonary disease and lung function: a prospective cohort study of UK biobank.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) pathogenesis involves the cross-links between inflammation, oxidative stress, and metabolic dysregulation leading to irreversible airflow limitation. The metabolic vulnerability index (MVX) integrates inflammation and metabolic malnutrition related metabolic biomarkers that may reflect these underlying mechanisms. This study aimed to assess the associations of MVX score with risk of incident COPD and lung function in the UK Biobank.

Methods

The sex-specific MVI score was developed as a composite biomarker, which integrates six nuclear magnetic resonance (NMR)-based plasma biomarkers, including glycoprotein acetyls (GlycA), small high-density lipoprotein particles (sHDL), citrate, and the branched-chain amino acids (isol

SUBMITTER: Jin C 

PROVIDER: S-EPMC12659030 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature