Extracellular vesicles for delivery of functional telomerase.

ABSTRACT:

Background

Telomerase, essential for maintaining chromosomal telomere integrity and preventing cellular senescence, represents a promising therapeutic target. However, the inherent risks associated with existing treatments for telomerase deficiency-related diseases necessitate the development of safe and precise targeted delivery systems capable of reaching specific cell populations. Extracellular vesicles (EVs), nanoscale membrane-bound particles naturally secreted by cells, mediate intercellular communication by transporting bioactive molecules, including proteins and nucleic acids. We hypothesized that EVs could function as intrinsic vehicles for telomerase delivery.

Methods

To investigate this, we demonstrated the effective encapsulation of functional telomerase componen

SUBMITTER: He Y 

PROVIDER: S-EPMC12659060 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature