Catastrophic antiphospholipid syndrome following surgery for Libman-Sacks endocarditis: A case report and literature review.

ABSTRACT:

Objective

To report a rare case of catastrophic antiphospholipid syndrome (CAPS) following surgery for Libman-Sacks endocarditis (LSE), and to clarify the clinical relationship between antiphospholipid syndrome (APS), LSE and CAPS.

Methods

We analysed the clinical course of a patient who developed CAPS after mitral valve replacement surgery for LSE. A literature review was conducted to explore the systemic nature of APS and its cardiac and thrombotic manifestations.

Results

A 53-year-old woman initially presented with cerebral infarction and was found to have mitral valve vegetations. Although APS-associated features were present before surgery, a diagnosis was not established at that time. Postoperatively, the patient developed multiple thrombotic events affecting th

SUBMITTER: Li Y 

PROVIDER: S-EPMC12659077 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature