Predictive enrichment using biomarkers in studies of critically-ill patients with sepsis: a systematic review.

ABSTRACT:

Background

Sepsis remains one of the most prevalent conditions necessitating admission to intensive care units and is associated with high mortality. Unfortunately, randomized trials examining therapeutics for critically-ill patients with sepsis have been disproportionately negative, failing to identify effective interventions, likely due to the dilution of treatment effects across highly diverse populations. Designing trials to identify patients that are most likely to benefit from an intervention based on biologic mechanism, known as predictive enrichment, may be an effective strategy for enhancing clinical trial efficacy. We conducted a systematic review to summarize the use of biological markers (biomarkers) used for predictive enrichment in randomized controlled trials (RCTs)

SUBMITTER: Van Nynatten LR 

PROVIDER: S-EPMC12659080 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature