Temporal changes in amino acid profiles coordinate mosquito physiology and egg maturation in Aedes aegypti.

ABSTRACT:

Background

Female Aedes aegypti mosquitoes utilize host blood to support egg maturation by digesting, absorbing, and metabolizing its components. Among these, amino acids are essential as both signaling molecules and building blocks for yolk proteins. While their overall importance is established, the individual dynamics and regulation of each amino acid remain insufficiently understood.

Results

We systematically profiled free and protein-bound amino acids in whole bodies, ovaries, and excreta over time after blood feeding, revealing distinct temporal dynamics across amino acids. Notably, tyrosine, enriched in yolk proteins, exhibited a biphasic pattern: a transient decrease between 6 and 9 h post blood meal, followed by accumulation during egg maturation. We also performed

SUBMITTER: Kato Y 

PROVIDER: S-EPMC12659091 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature