Neutrophil cathepsin G and risk of cardiovascular events in patients with diabetes mellitus.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is a major risk factor for atherosclerosis and cardiovascular events (CVEs), partly due to increased platelet activation and inflammation. Neutrophil-derived cathepsin G (CatG), a prothrombotic protease, may play a role in this process by promoting platelet aggregation. However, its association with CVEs in T2DM has not been previously explored. This study aimed to evaluate whether circulating CatG levels independently predict CVEs in patients with T2DM.

Methods

We included 485 T2DM patients from two prospective cohorts (PLINIO and ATHERO-AF studies). The primary outcome was a composite of cardiovascular death, non-fatal coronary and cerebrovascular events, and peripheral artery events. Cardiovascular death, all-cause death, non-fat

SUBMITTER: Baratta F 

PROVIDER: S-EPMC12659094 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature