Inhalation toxicity of arsenic-containing mine dust in an air-liquid interface bronchial epithelial model.

ABSTRACT:

Background

Tin mine dust (MD), a by-product of tin mining and rock drilling, is a significant contributor to miners' pneumoconiosis. This aerosolized dust is a complex mixture of mineral components, including potentially toxic heavy metals such as arsenic, which may contribute to the development of pneumoconiosis and lung cancer. This study investigates the inhalation toxicity of tin MD samples on pulmonary cells using an Air-Liquid Interface (ALI) exposure model.

Results

MD-A was characterized by high arsenic content, exceeding 30%. In contrast, the elemental composition of MD-B and MD-C was predominantly composed of calcium, magnesium, and aluminum. In the toxicity study, key toxicological endpoints (cell viability, cytotoxicity, pro-inflammatory markers, and cell barrier

SUBMITTER: Ji X 

PROVIDER: S-EPMC12659116 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature