Multiomic analyses on the contribution of transposable elements to the cis-regulatory landscape of different types of immune cells.

ABSTRACT:

Background

Transposable elements (TEs) are mobile DNA elements abundant in eukaryote genomes. While recognized as key contributors to cis-regulatory elements (CREs), their association with the cell-specific regulatory landscape of various immune cells remain largely unclear. This study aims at depicting the association of TEs with the CREs in diverse types of human immune cells in peripheral blood, with special focus on monocytes which are crucial for innate immunity.

Results

Using single-cell multiomic data of human peripheral blood mononuclear cells (PBMCs), we annotated the cell-specific CREs (csCREs) for different immune cell types, including sub-populations of B/T lymphocytes, monocytes, natural killer cells, and dendritic cells. A total of 63 TE families are significan

SUBMITTER: Du C 

PROVIDER: S-EPMC12659123 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature