Association of DRD4 promoter-associated methylation with mild cognitive impairment in Han and Uygur populations.

ABSTRACT:

Background

Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease characterized by subjective cognitive decline and objective evidence of cognitive impairment revealed through neuropsychological examinations. Dopamine receptors play a pivotal role in the modulation of memory and cognitive functions. DRD4 is a dopamine receptor gene enriched in memory-related brain regions, modulates synaptic plasticity, and its promoter methylation status. While DRD4 promoter methylation is implicated in neurodevelopmental disorders, its role in MCI pathogenesis remains uninvestigated across ethnically diverse populations.

Purpose

Our study focused on the association between DRD4 methylation and MCI in Uygur and Han populations.

Patients and methods

192 age-sex-ma

SUBMITTER: Xu C 

PROVIDER: S-EPMC12659133 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature