Decellularized bone extracellular matrix embedded with PLGA-linezolid microparticles for infected bone regeneration.

ABSTRACT:

Background

Dual-functional antibacterial and osteogenic substitutes are advanced tools for treating bone infections while facilitating bone regeneration. These systems incorporate drug delivery mechanisms that allow for the local release of antibiotics and increased treatment efficacy. Decellularized bone extracellular matrix (dECM) offers key advantages for bone xenografts and local drug delivery due to its biocompatibility and low immunogenicity. This study developed a novel scaffold by loading linezolid-poly (lactic-co-glycolic acid) (PLGA-Lin) microparticles onto dECM derived from bovine tibia. The antibacterial activity, cytocompatibility, and osteoconductive properties of the resulting Lin-PLGA/dECM scaffold were assessed in vitro.

Results

The results revealed that the

SUBMITTER: Ebrahimi F 

PROVIDER: S-EPMC12659149 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature