Efficacy and safety of stereotactic radiosurgery for hypothalamic hamartomas: a systematic review and meta-analysis.

ABSTRACT:

Background

Hypothalamic hamartomas (HHs) are congenital, non-neoplastic tumors originating from the hypothalamic region. While surgical resection remains the standard treatment, it is associated with substantial morbidity, leading to the exploration of minimally invasive approaches such as radiofrequency thermocoagulation (RFTC), laser interstitial thermal therapy (LiTT), and stereotactic radiosurgery (SRS). This systematic review and meta-analysis evaluate the efficacy and safety of SRS in managing HHs, with a focus on seizure control, endocrine function, and treatment-related complications.

Methods

A comprehensive literature search was conducted on December 6, 2024, using PubMed, Embase, Scopus, and Web of Science. Studies that evaluated the role of SRS in HH patients were

SUBMITTER: Hajikarimloo B 

PROVIDER: S-EPMC12659174 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature