Protein kinase D2-mediated maintenance complex component 2 phosphorylation promotes bladder cancer progression.

ABSTRACT:

Background

Bladder cancer, a widely occurring malignant tumor worldwide, is closely related to the abnormal activation of numerous signaling pathways during its initiation, progression, and metastasis. Protein kinase D2 (PRKD2), as a member of the protein kinase D family, exerts a pivotal influence on human cancers. This research aimed to elucidate the involvement and mechanism of PRKD2 in bladder cancer.

Methods

PRKD2 expression was analyzed using quantitative real-time PCR, Western blotting and tissue microarray (n = 30). Functional experiments were conducted to evaluate the biological phenotypes of cells, including CCK-8 assay, colony formation assay, flow cytometry analysis, scratch wound healing assay, Transwell migration assay, and mouse xenograft model. The phosphoryl

SUBMITTER: Tian H 

PROVIDER: S-EPMC12659223 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature