An atypical case of overlapped anti-NMDA-R and anti-GFAP encephalitis secondary to a teratoma of the fallopian tube: a case report.

ABSTRACT:

Background

Anti-N-methyl-D-aspartate receptor (anti-NMDA-R) and glial fibrillary acidic protein (anti-GFAP) encephalitis are autoimmune conditions that can occur concurrently, often presenting with severe neurological symptoms. Coexistence of both antibodies has been associated with greater resistance to immunotherapy and a higher risk of underlying neoplasms, particularly teratomas, which are commonly linked to anti-NMDA-R encephalitis. Detecting such tumors is crucial, though standard imaging may fail to identify them, especially in atypical locations.

Case presentation

We report the case of a 32-year-old woman presenting with severe overlapping of anti-NMDA-R and anti-GFAP encephalitis. She required long-term admission to the intensive care unit and showed no improvement

SUBMITTER: Rivera Sanchez M 

PROVIDER: S-EPMC12659281 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature