Plasma inflammatory proteome profiles identify MASLD among children with overweight or obesity.

ABSTRACT:

Background & aims

Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent among children with overweight or obesity, yet its early diagnosis remains a major clinical challenge. This study aimed to identify circulating inflammatory proteins associated with MASLD and to develop a proteomic risk score (ProScore) to improve diagnostic accuracy.

Methods

In this cross-sectional study of 161 children (median age 8.5 years) with overweight or obesity, MASLD was assessed by vibration-controlled transient elastography, with 42 cases identified. Plasma concentrations of 92 inflammation-related proteins were quantified using a high-throughput proximity extension assay. The ProScore was compared with eleven conventional anthropometric/metaboli

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12659286 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature