Transcriptional deregulation by FOXM1-JUP signaling confers dual oncogenic drivers for pancreatic tumorigenesis and therapeutic resistance.

ABSTRACT:

Purpose

Junction plakoglobin (JUP/γ-catenin) is a dual-component cell adhesion molecule of adherens junctions and desmosomes, maintaining epithelial homeostasis while paradoxically involving oncogenic transformation. In pancreatic ductal adenocarcinoma (PDAC), the mechanistic role and clinical implications of JUP signaling in oncogenic reprogramming remains undefined.

Experimental design

Gene expression and its association with clinicopathologic characteristics and therapeutic resistance of patients with PDAC were analyzed using IHC and bioinformatics and functionally validated by using mouse models. Protein expression and their regulation were measured by using gain- and loss-of-function assays and molecular biology methods.

Results

Our immunostaining results and bio

SUBMITTER: Yang K 

PROVIDER: S-EPMC12659345 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature