The Utility of CSF Biomarkers in Diagnosing Alzheimer's Disease: A Thai Cohort Study.

ABSTRACT:

Introduction

Cutoff values for cerebrospinal fluid biomarkers vary by analytic technique and population, which complicates the differentiation of Alzheimer's disease (AD) from non-AD dementias. We aimed to establish local cerebrospinal fluid biomarker cutoffs within a Thai cohort.

Materials and methods

We recruited 68 patients with various forms of dementia from the Memory Clinic at Siriraj Hospital, Thailand. Each patient underwent clinical subtyping for dementia, and their cerebrospinal fluid levels of Aβ42, p-tau181, and t-tau were quantified using the Fujirebio INNOTEST ELISA. We then employed a data-driven approach, specifically a Z-score-based Gaussian Mixture Model, to define intersection cutoffs for Aβ42, p-tau181, t-tau, and the p-tau181/Aβ42 ratio. These establishe

SUBMITTER: Nanthasi W 

PROVIDER: S-EPMC12659453 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature