Comparative outcomes of neoadjuvant chemotherapy versus upfront surgical resection in osteosarcoma: a systematic review and meta-analysis.

ABSTRACT:

Background

Osteosarcoma is an aggressive primary bone tumor commonly managed with multimodal therapy; however, the optimal sequencing of chemotherapy and surgery remains debated. Neoadjuvant chemotherapy (NACT) is widely used to facilitate limb-salvage surgery (LSS) and assess histologic response, yet its comparative benefit over upfront surgical resection remains unclear. This systematic review and meta-analysis aimed to compare oncologic and surgical outcomes between NACT followed by surgery versus upfront surgical resection in patients with osteosarcoma.

Methods

A systematic search of PubMed, CENTRAL, and Google Scholar was conducted up to June 2025. Eligible studies included patients with histologically confirmed osteosarcoma treated with NACT plus surgery or upfront sur

SUBMITTER: Alaseem A 

PROVIDER: S-EPMC12659466 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature