Assisted reproductive technology and reproductive, perinatal, and maternal outcomes: evidence from an umbrella review of systematic reviews with meta-analyses of randomized controlled trials.

ABSTRACT:

Background

The expanding global use of assisted reproductive technology (ART) warrants rigorous evidence synthesis. This umbrella review (UR) evaluated the strength and validity of evidence on ART effects on reproductive, perinatal, and maternal outcomes.

Methods

We searched five databases and reference lists (Inception to 15 June 2025) to identify systematic reviews with meta-analyses of randomized controlled trials (RCTs). For each extracted association, we performed a reanalysis using random-effects models, calculated the 95% prediction interval, heterogeneity, small-study effect, and evaluated excess significance bias. The quality of systematic reviews was evaluated using A Measurement Tool to Assess Systematic Reviews (AMSTAR). The certainty of evidence was assessed usi

SUBMITTER: Wang DD 

PROVIDER: S-EPMC12659476 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature