Semaphorin 5A modulates focal adhesion pathway and lamellipodia formation in melanoma.

ABSTRACT:

Introduction

Metastatic potential and rising incidence make cutaneous melanoma a major health concern worldwide. While current therapies have proven effective, they are limited by side effects arising and by the development of drug resistance. For this reason, identifying new therapeutic targets and predictive biomarkers is crucial. Semaphorin 5 A (SEMA5A) is a member of the Semaphorin family, implicated in both cancer biology and neural development. We have previously demonstrated that this protein promotes different aggressive features of melanoma cells. In this study, we conducted a more in-depth investigation into the role of SEMA5A in the development and progression of melanoma.

Methods

We performed proteomic and in silico analysis of stable knockdown SEMA5A human melan

SUBMITTER: Brignone M 

PROVIDER: S-EPMC12659518 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature