Mortality attributable to modifiable lifestyle factors in the Spanish cohort of the European prospective investigation into cancer and nutrition (EPIC) study.

ABSTRACT:

Background

There is consistent evidence on the relationship of unhealthy habits with mortality risk. The population attributable fraction (PAF) is a useful quantifier of the number of new disease cases attributable to modifiable risk factors. Our objective was to obtain the hazard ratios (HRs) and the PAFs for the major individual lifestyle factors of mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Methods

Prospective study which included 40 307 EPIC-Spain participants (62.5% women). A total of 7 262 cases of all-cause mortality (53.9% were men) occurred during an average follow-up of 25.1 years. We calculated PAFs separately for men and women, using adjusted HRs of mortality (and 95% CI) from multivariate Cox

SUBMITTER: Cirera L 

PROVIDER: S-EPMC12659519 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature