Functional archetypes in the human gut microbiome reveal metabolic diversity, stability, and influence disease-associated signatures.

ABSTRACT:

Background

Understanding the functional diversity of the gut microbiome is critical for elucidating its roles in human health and disease. While traditional approaches focus on taxonomic composition, functional configurations of the microbiome remain understudied. This study introduces a deep-learning framework combined with archetypal analysis to identify and characterize functional archetypes in the adult human gut microbiome. This approach aims to provide insights into interindividual variability, function-driven microbiome stability, and the potential confounding role of functional diversity in disease-associated microbial signatures.

Results

Analyzing 9838 whole-genome metagenomic samples from healthy adults across 29 countries, we identified three distinct functional a

SUBMITTER: Meawad M 

PROVIDER: S-EPMC12659530 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature