Human papillomavirus seminal carriage alters virome diversity and male fertility: a case-control study.

ABSTRACT:

Background

A link between idiopathic male infertility and viral infections exhibiting seminal carriage has emerged recently. In this respect, human papillomavirus (HPV) appears to be the most prevalent sexually transmitted agent worldwide. The viruses present in the genital environment comprise the genital virome. HPV infection reportedly disrupts homeostasis of the virome in women but this topic has not previously been studied in men.

Methods

This was a retrospective study of males attending the fertility clinic at Amiens University Medical Center (Amiens, France). Men with a multiple-type HPV infection in the sperm (n = 15) were considered to be cases, and men with no detectable HPV in the sperm were considered to be controls (n = 13). The molecular virome in cases and con

SUBMITTER: Kansou E 

PROVIDER: S-EPMC12659567 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature